Description

MOTS-c — Research Use Only

Overview

A synthetic 16-amino-acid peptide, supplied as a laboratory reagent.

Chemical Identification

Research Areas

• A 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region (MT-RNR1), an unusual example of a bioactive peptide with mitochondrial rather than nuclear origin.
• The original 2015 study (Lee et al., Cell Metabolism) examined it in mouse models of diet-induced obesity and insulin resistance.
• Research has examined AMPK activation and the folate-purine metabolic pathway in skeletal muscle.
• Animal studies have examined exercise-induced expression and its association with muscle homeostasis and age-related physical decline.
• Published work has also examined signalling in vascular calcification, myocardial remodelling and pancreatic islet senescence models.
• Human studies have measured circulating MOTS-c levels in relation to exercise, without administering the peptide.

Selected Reference

Third-party publications listed for reference only. Listing a paper is not a claim about the use of this product.

• Wan W, et al. (2023). Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging. Journal of Translational Medicine, 21, 36. View on PMC

Handling and Storage

Supplied as a lyophilised powder in a sealed vial. Store as stated above, protected from light and moisture, and avoid repeated freeze-thaw cycles. Any reconstitution must take place in a controlled laboratory setting.

Certificate of Analysis

Purity is specified per batch. The independent third-party batch report for this product is available on request. Email Contact@huntresearchlabs.com with the product name and your order number.

Regulatory Note

This product is not a licensed medicine and has not been evaluated by the MHRA, FDA or any other regulator for any use. It is supplied for in vitro laboratory research only.

Research Use Disclaimer: This product is intended exclusively for laboratory research and in vitro use by qualified researchers. It is not for human or veterinary consumption, diagnostic use, or therapeutic application. See our full Terms and Conditions of Research Use for complete usage terms.