Description
TB-500 (Thymosin Beta-4) — Research Use Only
Overview
A synthetic 43-amino-acid peptide, supplied as a laboratory reagent. Some suppliers use the name TB-500 for a shorter fragment (Ac-LKKTETQ-OH); check the batch Certificate of Analysis to confirm the form supplied.
Chemical Identification
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH |
| Molecular formula | C212H350N56O78S |
| Molecular weight | 4963.44 g/mol |
| CAS number | 77591-33-4 |
| Purity | 98.44% (supplier batch report, 20 May 2026) |
| Storage | -20°C |
Research Areas
- Thymosin beta-4 is a 43-amino-acid peptide found in platelets and most tissue types. It is not a growth factor but an actin-sequestering peptide that binds monomeric (G-) actin, and its role in cell motility and cytoskeletal dynamics has been characterised.
- In vitro work has examined PDGF-BB-stimulated proliferation and migration of hepatic stellate cells at defined concentrations.
- Animal studies have used topical application in wound-closure models, with healing time as the measured endpoint.
- Murine skeletal muscle injury models have examined Tβ4 expression during regeneration. The sulfoxide form has been studied for its chemotactic effect on myoblasts derived from muscle satellite cells.
- Animal studies (Bock-Marquette et al., Nature, 2004) examined its activation of integrin-linked kinase and effects on cardiac cell migration and survival.
- LC/MS methods for detecting Tβ4-related peptides and metabolites have been developed for doping-control research.
- Much of the published work concerns full-length thymosin beta-4 rather than the fragment sometimes sold as TB-500.
Handling and Storage
Supplied as a lyophilised powder in a sealed vial. Store as stated above, protected from light and moisture, and avoid repeated freeze-thaw cycles. Any reconstitution must take place in a controlled laboratory setting.
Certificate of Analysis
Purity is specified per batch. The independent third-party batch report for this product is available on request. Email Contact@huntresearchlabs.com with the product name and your order number.
Regulatory Note
This product is not a licensed medicine and has not been evaluated by the MHRA, FDA or any other regulator for any use. It is supplied for in vitro laboratory research only.
Research Use Disclaimer: This product is intended exclusively for laboratory research and in vitro use by qualified researchers. It is not for human or veterinary consumption, diagnostic use, or therapeutic application. See our full Terms and Conditions of Research Use for complete usage terms.
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